期刊
FEMS MICROBIOLOGY REVIEWS
卷 42, 期 3, 页码 376-387出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsre/fuy010
关键词
Argonaute; DNA-guided DNA silencing; antiviral defense; archaea; bacteria; prokaryotic Argonaute
类别
资金
- Deutsche Forschungsgemeinschaft [DFG] [GR 3840/2-1, SFB960-TP7]
- intramural program of the US Department of Health and Human Services
Argonaute (Ago) proteins are encoded in all three domains of life and are responsible for the regulation of intracellular nucleic acid levels. Whereas some Ago variants are able to cleave target nucleic acids by their endonucleolytic activity, others only bind to their target nucleic acids while target cleavage is mediated by other effector proteins. Although all Ago proteins show a high degree of overall structural homology, the nature of the nucleic acid binding partners differs significantly. Recent structural and functional data have provided intriguing new insights into the mechanisms of archaeal and bacterial Ago variants demonstrating the mechanistic diversity within the prokaryotic Ago family with astonishing differences in nucleic acid selection and nuclease specificity. In this review, we provide an overview of the structural organisation of archaeal Ago variants and discuss the current understanding of their biological functions that differ significantly from their eukaryotic counterparts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据