期刊
PSYCHOPHARMACOLOGY
卷 234, 期 13, 页码 1997-2007出版社
SPRINGER
DOI: 10.1007/s00213-017-4607-8
关键词
Methamphetamine; Naltrexone; Craving; Subjective response
资金
- National Institute on Drug Abuse [DA029831, F31 DA035604]
- UCLA Clinical and Translational Science Institute [UL1RR033176, UL1TR000124]
- California Tobacco Related Disease Research Program [18KT-0020, T32 DA024635]
- National Institutes of Alcohol Abuse and Alcoholism [F31 AA022569]
- Thomas P. and Katherine K. Pike Chair in Addiction Studies
- Marjorie Greene Family Trust
Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapies on this relationship has been examined. This secondary data analysis sought to examine (1) the predictive relationship between cue-induced craving and subsequent acute subjective response to methamphetamine (MA) and (2) whether the opioid-receptor antagonist naltrexone moderated this association in a sample of non-treatment-seeking individuals who met DSM-IV criteria for MA use disorder (abuse or dependence). Participants (n = 30) completed two 4-day medication regimens (oral naltrexone 50 mg or placebo, in a randomized, counterbalanced, and double-blind fashion). On day 4 of each medication regimen, participants completed a cue-reactivity paradigm followed by intravenous MA administration. Methamphetamine craving was assessed after the cue-reactivity paradigm, and subjective response to MA was assessed during MA infusion. Cue-induced craving for MA was positively associated with post-infusion subjective MA effects, including positive (i.e., stimulation, good effects, feel drug, high), negative (i.e., anxious and depressed), and craving-related (i.e., want more, would like access to drug, crave) responses. Naltrexone, vs. placebo, significantly reduced the association between cue-induced craving and positive subjective response to MA. The findings indicate that naltrexone moderates the predictive relationship between cue-induced craving and positive subjective effects of MA, thereby suggesting a behavioral mechanism by which naltrexone may be efficacious in treating MA use disorder.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据