期刊
PSYCHONEUROENDOCRINOLOGY
卷 85, 期 -, 页码 210-214出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2017.08.016
关键词
Stress; Mindfulness; Epigenetics; Methylation; Biological aging; Blood
资金
- CNRS PEPS INEE
- NCCAM [P01-AT004952]
- Fetzer Institute
- John Templeton Foundation
- LABEX CORTEX [ANR-11-LABX-0042]
- Universite de Lyon [ANR-11-IDEX-0007]
- ERC [617739-BRAINandMINDFULNESS]
In this paper, we examined whether meditation practice influences the epigenetic clock, a strong and reproducible biomarker of biological aging, which is accelerated by cumulative lifetime stress and with age-related chronic diseases. Using the Illumina 450 K array platform, we analyzed the DNA methylome from blood cells of long-term meditators and meditation-naive controls to estimate their Intrinsic Epigenetic Age Acceleration (IEAA), using Horvath's calculator. IEAA was similar in both groups. However, controls showed a different IEAA trajectory with aging than meditators: older controls (age 52) had significantly higher IEAA5 compared with younger controls (age < 52), while meditators were protected from this epigenetic aging effect. Notably, in the meditation group, we found a significant negative correlation between IEAA and the number of years of regular meditation practice. From our results, we hypothesize that the cumulative effects of a regular meditation practice may, in the long-term, help to slow the epigenetic clock and could represent a useful preventive strategy for age-related chronic diseases. Longitudinal randomized controlled trials in larger cohorts are warranted to confirm and further characterize these findings.
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