期刊
NATURE REVIEWS IMMUNOLOGY
卷 18, 期 5, 页码 325-339出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2017.143
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资金
- Wellcome Centre
- Royal Society
- National Health and Medical Research Council (Australia)
- Cancer Council of Victoria
- Australian Research Council (ARC)
- Worldwide Cancer Research
- Medical Research Council
- Danish National Research Foundation
- Takeda
- Oak Foundation
- Wellcome Trust [100308/Z/12/Z] Funding Source: Wellcome Trust
- MRC [MC_UU_00008/3] Funding Source: UKRI
- Medical Research Council [MC_UU_00008/3] Funding Source: researchfish
- Rosetrees Trust [M85-F1] Funding Source: researchfish
- Wellcome Trust [100308/Z/12/Z] Funding Source: researchfish
Fifty years since the first description of an association between HLA and human disease, HLA molecules have proven to be central to physiology, protective immunity and deleterious, disease-causing autoimmune reactivity. Technological advances have enabled pivotal progress in the determination of the molecular mechanisms that underpin the association between HLA genetics and functional outcome. Here, we review our current understanding of HLA molecules as the fundamental platform for immune surveillance and responsiveness in health and disease. We evaluate the scope for personalized antigen-specific disease prevention, whereby harnessing HLA-ligand interactions for clinical benefit is becoming a realistic prospect.
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