期刊
ENVIRONMENTAL HEALTH PERSPECTIVES
卷 124, 期 4, 页码 514-520出版社
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/ehp.1408750
关键词
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资金
- National Institute of Environmental Health Sciences (NIEHS)/National Institutes of Health (NIH)
- U.S. Environmental Protection Agency (EPA)
- Robert Wood Johnson Foundation
- National Institute of Diabetes and Digestive and Kidney Diseases
- NIEHS [5P01ES09600, 5R01ES08977, R01ES010165, R01ES015282]
- U.S. EPA [R827027, 8260901, RR00645]
- Educational Foundation of America
- John and Wendy Neu Family Foundation
- New York Community Trust
- Trustees of the Blanchette Hooker Rockefeller Fund
- NIH T32 Training Grant [5T32DK06552-07]
BACKGROUND: Phthalate exposures are hypothesized to increase obesity; however, prior research has been largely cross-sectional. OBJECTIVE: We evaluated associations between prenatal phthalate exposures and body mass index (BMI) at child ages 5 and 7 years. METHODS: Nine metabolites of six phthalates-di(2-ethylhexyl) phthalate (DEHP), di-n-octyl-, di-iso-butyl-, di-n-butyl-, butylbenzyl-, and diethyl phthalates-were measured in spot urine samples collected from pregnant African-American and Dominican women during their third trimester, and from their children at ages 3 and 5 years. To reduce multiple comparison issues, we initially used principal component analysis (PCA) to identify major patterns of natural log (ln)-transformed metabolite concentrations. Height and weight were assessed at ages 5 and 7 years, and fat mass and waist circumference at age 7. Linearized generalized estimating equation analyses related maternal component scores to child anthropometric outcomes at ages 5 (n = 326) and 7 (n = 330) years. RESULTS: PCA identified a DEHP component and a non-DEHP component. In boys, higher maternal non-DEHP, but not DEHP, component scores were associated with lower BMI z-score (beta = -0.30; 95% CI: -0.50, -0.10, n = 156), lower fat percentage (beta = -1.62; 95% CI: -2.91, -0.34, n = 142), and smaller waist circumference (beta = -2.02; 95% CI: -3.71, -0.32, n = 124). No significant associations with anthropometric outcomes were seen in girls (for BMI z-score, beta = 0.07; 95% CI: -0.18, 0.31, n = 181). Interactions between sex and non-DEHP component association with outcomes were statistically significant (p < 0.01). CONCLUSIONS: Contrary to hypotheses, prenatal non-DEHP phthalate exposures were associated with lower BMI z-score, waist circumference, and fat mass in boys during early childhood.
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