期刊
PHYSIOLOGICAL REPORTS
卷 6, 期 7, 页码 -出版社
WILEY
DOI: 10.14814/phy2.13649
关键词
Endotoxemia; glucose control; intestinal microbiota; intestinal permeability; type 2 diabetes
类别
资金
- National Institute for Health Research (NIHR) Clinical Research Network (CRN): Kent, Surrey and Sussex
- NERC [NE/L011956/1]
- FNRS, PDR (Projet de Recherche) [T.0138.14]
- FRFS-WELBIO [WELBIO-CR-2012S-02R]
- Funds Baillet Latour
- ERC Starting Grant [336452-ENIGMO]
- EFSD clinical research grant
- NERC [NE/L011956/1] Funding Source: UKRI
Type 2 diabetes (T2D) has been linked with increased intestinal permeability, but the clinical significance of this phenomenon remains unknown. The objective of this study was to investigate the potential link between glucose control, intestinal permeability, diet and intestinal microbiota in patients with T2D. Thirty-two males with well-controlled T2D and 30 age-matched male controls without diabetes were enrolled in a case-control study. Metabolic parameters, inflammatory markers, endotoxemia, and intestinal microbiota in individuals subdivided into high (HP) and normal (LP) colonic permeability groups, were the main outcomes. In T2D, the HP group had significantly higher fasting glucose (P = 0.034) and plasma nonesterified fatty acid levels (P = 0.049) compared with the LP group. Increased colonic permeability was also linked with altered abundances of selected microbial taxa. The microbiota of both T2D and control HP groups was enriched with Enterobacteriales. In conclusion, high intestinal permeability was associated with poorer fasting glucose control in T2D patients and changes in some microbial taxa in both T2D patients and nondiabetic controls. Therefore, enrichment in the gram-negative order Enterobacteriales may characterize impaired colonic permeability prior to/independently from a disruption in glucose tolerance.
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