期刊
PSYCHIATRY RESEARCH
卷 254, 期 -, 页码 301-310出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2017.05.006
关键词
Mirtazapine; Cocaine; Pharmacotherapy; Locomotor sensitization; Drug addiction; 5-HT receptors; Alpha receptors
类别
资金
- Gonzalo Rios Arronte Fundation
- Merck Sharp & Dome/Schering-Plough Mexico
- CONADIC
- [INP-2040]
- [SEP-CONACYT-2009-10003-106549]
- [ICyT PINV11-26]
Relapse to cocaine use is a major problem in the clinical treatment of cocaine dependence. Antidepressant medications have been studied as potential therapeutic drugs to relieve a cocaine dependence disorder. Mirtazapine is an antidepressant implicated in reducing behavioral alterations induced by drugs of abuse. We have reported elsewhere that 30 mg/kg mirtazapine administered for 30 days during cocaine extinction significantly attenuated the induction and expression of cocaine-induced locomotor sensitization and decreased the duration of the cocaine-induced locomotor effect. This study focused on exploring whether different mirtazapine dosing regimens could optimize and/or improve the effect of 30 mg/kg mirtazapine administered for 30 days on cocaine-induced locomotor activity during the expression phase of behavioral sensitization. Our study revealed that the daily dosing regimen with a fixed dose of mirtazapine (30 mg/kg ip) over 60 days improved the decrease in cocaine-induced locomotor activity and behavioral sensitization obtained by dosing of 30 mg mirtazapine for 30 days. In addition, it showed that a dosing regimen of 30 mg/Kg mirtazapine for 30 days managed to reduce cocaine toxicity. These results suggested that dosage of mirtazapine for 30 consecutive days may be an effective therapy.
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