期刊
PSYCHIATRY RESEARCH
卷 252, 期 -, 页码 175-179出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2017.02.058
关键词
Open Essence test; Neuropsychiatric disorders; Olfactory function; Dementia; Alzheimer's disease
类别
资金
- Japan Society for the Promotion of Science (JSPS) [16K19784]
- Kanazawa Medical University [SR2012-03]
- Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT)-Program for the Strategic Research Foundation at Private Universities [S1201022]
- Grants-in-Aid for Scientific Research [16K19784] Funding Source: KAKEN
Recent clinical studies have identified olfactory dysfunction in patients with neuropsychiatric disorders. Although these studies showed differences in olfactory function between healthy individuals and neuropsychiatric patients, no studies have compared the differences in olfactory function among neuropsychiatric disorders. The aim of the present study was to investigate olfactory function among various neuropsychiatric disorders. Three-hundred and eighteen outpatients diagnosed according to the ICD-10 code participated in the study. Olfactory function was assessed using the Open Essence test. The differences in olfactory function among disorders were compared by analyses of (co-)variance. As expected, olfactory function was significantly affected by the age and marginally affected by the gender. We investigated the differences in olfactory function among patients with different neuropsychiatric disorders (FO-F9). Olfactory function significantly differed among the diagnostic groups. Post hoc analysis showed that patients with FO had decreased olfactory function compared to patients from the other diagnostic groups. In particular, patients with Alzheimer's disease (AD) had significantly poorer olfactory function compared to patients with other neuropsychiatric disorders. There were no differences among the other groups. These findings suggest that patients with AD had poorer olfactory function compared not only to healthy subjects but also to patients with several other neuropsychiatric disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据