期刊
PSYCHIATRY RESEARCH
卷 249, 期 -, 页码 304-306出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2017.01.002
关键词
Suicide; Polymorphism; Exercise
类别
资金
- Bureau of Medicine and Surgery, Wounded, Ill, and Injured Program [16.591]
- Office of Naval Research [N1314]
We evaluated associations of five candidate polymorphisms (Bell [rs41423247], 2C/G [rs2070951], COMT [rs737865], Va166Met [rs6265], and 5HTTLPR [biallelic and triallelic [5HTTLPR/rs25531]) with probable MDD and suicidal ideation (SI), the effects of physical activity on these endpoints, and whether physical activity attenuates genetic risk in military members (N=736). C carriers who were also less physically active were 3.3 times as likely to meet criteria for probable MDD and 9.6 times as likely to endorse SI as compared to physically active GG carriers. An adequate dose of physical activity diminishes risk of MDD and SI imposed by a genetic predisposition.
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