期刊
PROTEIN AND PEPTIDE LETTERS
卷 24, 期 9, 页码 809-816出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929866524666170728151401
关键词
Physical exercise; physical training; renin angiotensin system; ACE2; angiotensin-(1-7); Mas receptor
资金
- CNPq (Conselho Nacional de Pesquisa)
- FAPEMIG (Fundacao de Amparo a Pesquisa do Estado de Minas Gerais)
Background: Many physiological responses of the Renin Angiotensin System (RAS) are associated with two opposite pathways: (1) a classical one formed by angiotensin-converting enzyme (ACE), Angiotensin II (Ang II) and Angiotensin type 1 (AT(1)) receptor, which is associated to vasoconstriction, cell proliferation, organ hypertrophy, sodium retention and aldosterone release and (2) a counter-regulatory or vasodilator pathway comprising angiotensin-converting enzyme 2 (ACE2), Angiotensin-(1-7) [Ang-(1-7)] and Mas receptor, which is involved in vasodilation, anti-proliferation, anti-hypertrophy, cardioprotective and renoprotective actions. Objective: This review aimed to bring up-to-date on the interactions between physical exercise and the vasodilator axis of the RAS (ACE2-Ang-(1-7)-Mas receptor axis). We also investigated the relation of acute and chronic exercise with blood pressure regulation and components of the vasodilator axis of the RAS. Methods: We searched studies with animal models and humans in PUBMED, LILACS and IBECS. Results: Experimental studies showed that physical training can stimulate ACE2-Ang-(1-7)-Mas receptor axis in parallel with the inhibition of ACE-Ang II-AT1 receptor pathway. However, up to now, the interaction between the counter-regulatory RAS axis and physical training is not investigated in humans. Conclusion: The activation of ACE2-Ang-(1-7)-Mas receptor axis may have a role in the beneficial effects of physical training in experimental models. Further studies with humans are necessary.
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