期刊
PROGRESS IN NEUROBIOLOGY
卷 155, 期 -, 页码 149-170出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2015.09.011
关键词
Dopamine; Ecstasy; Methamphetamine; METH; 3,4-Methylenedioxymethamphetamine; MDMA; Mouse; Neurodegeneration; Neuroinflammation neurotoxicity; Non-human primate; Rat
资金
- Spanish Ministerios de Economia y Competitividad [SAF2013-48532-R]
- Sanidad Politica Social e Igualdad (PNSD) [2012/071, CIBERNED CB06/05/0055]
- Comunidad de Madrid [S2011/BMD-2336]
- Regione Autonoma della Sardegna
- Sardinian Regional Government
Amphetamine-related drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), are popular recreational psychostimulants. Several preclinical studies have demonstrated that, besides having the potential for abuse, amphetamine-related drugs may also elicit neurotoxic and neuroinflammatory effects. The neurotoxic potentials of MDMA and METH to dopaminergic and serotonergic neurons have been clearly demonstrated in both rodents and nonhuman primates. This review summarizes the species-specific cellular and molecular mechanisms involved in MDMA and METH-mediated neurotoxic and neuroinflammatory effects, along with the most important behavioral changes elicited by these substances in experimental animals and humans. Emphasis is placed on the neuropsychological and neurological consequences associated with the neuronal damage. Moreover, we point out the gap in our knowledge and the need for developing appropriate therapeutic strategies to manage the neurological problems associated with amphetamine-related drug abuse. (C) 2015 Elsevier Ltd. All rights reserved.
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