期刊
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
卷 76, 期 -, 页码 163-168出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2017.03.013
关键词
Schizophrenia; Cognitive functions; Brain-derived neurotrophic factor; Glial cell line-derived neurotrophic factor; Neurotrophins
资金
- Social Development Project by Science and Technology Bureau of Yangzhou City [YZ2014215, YZ2014025]
- Medical scientific research project of Jiangsu Provincial Commission of Health and Family Planning [Z201522]
- scientific research foundation of Jiangsu Provincial 333 Project [BRA2015541, BRA2016555]
Objectives: Evidence suggests that brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are important in the regulation of synaptic plasticity, which plays a key role in the cognitive processes in psychiatric disorders. Our work aimed at exploring the associations between serum BDNF and GDNF levels and cognitive functions in first-episode drug-naive (FEDN) patients with schizophrenia. Methods: The BDNF and GDNF levels of 58 FEDN patients and 55 age- and sex-matched healthy controls were measured and test subjects were examined using several neurocognitive tests including the verbal fluency test (VFT), the trail making test (TMT), the digit span test (DST), and the Stroop test. Results: Patients performed significantly worse than controls in nearly all neurocognitive performances except the forward subscale part of the DST. BDNF levels were inversely correlated to TMT-part B scores and positively correlated to VFT-action in the FEDN group. GDNF levels showed a positive correlation with VFT-action scores and a negative correlation with TMT-part B scores of these patients. Conclusion: Current data suggests that cognitive dysfunction widely exists in the early stages of schizophrenia. BDNF and GDNF may be jointly contributed to the pathological mechanisms involved in cognitive impairment in FEDN patients with schizophrenia.
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