期刊
BIOLOGICAL TRACE ELEMENT RESEARCH
卷 183, 期 2, 页码 335-341出版社
HUMANA PRESS INC
DOI: 10.1007/s12011-017-1152-6
关键词
Fluoride; Sulfur dioxide; Liver; DNA damage
资金
- National Natural Science Foundation of China [30172380]
- Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province
This study was aimed to evaluate the toxic effects of fluoride (F) and/or sulfur dioxide (SO2) on morphology and DNA integrity in liver of male rats. For this, 96 Wistar rats (12-week-old) were randomly divided into four groups after 1-week adaptive breeding: the control group, treated with deionized water; the NaF group, administered high F (100 mg NaF/L in the drinking water); the SO2 group, with sulfur dioxide in ambient air (15 ppm SO2, 4 h/day); and NaF + SO2 group, treated with high F and sulfur dioxide together for 8 consecutive weeks. The body weight, liver organ coefficient, morphology, and DNA damage in the liver of rats were examined. The results showed that the body weight and liver organ coefficient were not significantly changed; however, significant pathological changes of liver tissues were observed in the NaF + SO2 group compared with the individual treated groups and control group. Furthermore, comet assay indicated that DNA damage in liver was significantly increased in the F and/or SO2 treatment groups at 2, 4, 6, and 8 weeks, especially at 4 weeks. These results indicate that the liver morphology and DNA integrity of rats are adversely affected by F and/or SO2 exposure.
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