期刊
CANCER COMMUNICATIONS
卷 38, 期 -, 页码 -出版社
WILEY
DOI: 10.1186/s40880-018-0301-4
关键词
Lipid metabolism; Cancer; SCAP; SREBPs; Fatty acids; Cholesterol; Lipid droplets
类别
资金
- NIH [NS079701]
- American Cancer Society Research Scholar Grant [RSG-14-228-01-CSM]
- OSUCCC Idea Grant
- OSUCCC Translational Therapeutic Program
- Pelotonia Postdoc Fellowship
- OSU Department of Radiation-Oncology Basic Research seed Grant
Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy. Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth. Lipids constitute the basic structure of membranes and also function as signaling molecules and energy sources. Sterol regulatory element-binding proteins (SREBPs), a family of membrane-bound transcription factors in the endoplasmic reticulum, play a central role in the regulation of lipid metabolism. Recent studies have revealed that SREBPs are highly up-regulated in various cancers and promote tumor growth. SREBP cleavage-activating protein is a key transporter in the trafficking and activation of SREBPs as well as a critical glucose sensor, thus linking glucose metabolism and de novo lipid synthesis. Targeting altered lipid metabolic pathways has become a promising anti-cancer strategy. This review summarizes recent progress in our understanding of lipid metabolism regulation in malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment.
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