The inherited risk of retained placenta: a population based cohort study

ObjectiveTo investigate whether retained placenta in the first generation is associated with an increased risk of retained placenta in the second generation. DesignPopulation-based cohort study. SettingSweden. PopulationUsing linked generational data from the Swedish Medical Birth Register 1973-2012, we identified 494 000 second-generation births with information on the birth of the mother (first-generation index birth). For 292 897 of these births there was information also on the birth of the father. MethodsRisk of retained placenta in the second generation was calculated as adjusted odds ratios (aOR) by unconditional logistic regression with 95% confidence intervals (95% CI) according to whether retained placenta occurred in a first generation birth or not. Main outcomeRetained placenta in the second generation. ResultsThe risk of retained placenta in a second-generation birth was increased if retained placenta had occurred at the mother's own birth (aOR 1.66, 95% CI 1.52-1.82), at the birth of one of her siblings (aOR 1.58, 95% CI 1.43-1.76) or both (aOR 2.75, 95% CI 2.18-3.46). The risk was slightly increased if retained placenta had occurred at the birth of the father (aOR 1.23, 95% CI 1.07-1.41). For preterm births in both generations, the risk of retained placenta in the second generation was increased six-fold if retained placenta had occurred at the mother's birth (OR 6.55, 95% CI 2.68-16.02). ConclusionThere is an intergenerational recurrence of retained placenta on the maternal and most likely also on the paternal side. The recurrence risk seems strongest in preterm pregnancies. Tweetable abstractA population-based cohort study suggests that there is an intergenerational recurrence of retained placenta. Tweetable abstract A population-based cohort study suggests that there is an intergenerational recurrence of retained placenta.