期刊
CEREBRAL CORTEX
卷 28, 期 5, 页码 1733-1748出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhx083
关键词
gene expression; intracranial EEG; memory; neocortex
资金
- National Institutes of Health [R01DC014702, R01MH102603, R01MH103517, R21MH107672]
- James S. McDonnell Foundation 21st Century Science Initiative in Understanding Human Cognition Scholar Award [220 020 467]
- Alzheimer's Disease Center at UT Southwestern
- David M. Crowley Foundation
- UT BRAIN Initiative Seed Grant [366 582]
Memory encoding is an essential step for all learning. However, the genetic and molecular mechanisms underlying human memory encoding remain poorly understood, and how this molecular framework permits the emergence of specific patterns of brain oscillations observed during mnemonic processing is unknown. Here, we directly compare intracranial electroencephalography recordings from the neocortex in individuals performing an episodic memory task with human gene expression from the same areas. We identify genes correlated with oscillatory memory effects across 6 frequency bands. These genes are enriched for autism-related genes and have preferential expression in neurons, in particular genes encoding synaptic proteins and ion channels, supporting the idea that the genes regulating voltage gradients are involved in the modulation of oscillatory patterns during successful memory encoding across brain areas. Memory-related genes are distinct from those correlated with other forms of cognitive processing and resting state fMRI. These data are the first to identify correlations between gene expression and active human brain states as well as provide a molecular window into memory encoding oscillations in the human brain.
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