期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 114, 期 30, 页码 E6097-E6106出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1705065114
关键词
human immune variation; immune cell composition; systems immunology; aging
资金
- NIH [R01 HL120724]
- Ragon Institute of Massachusetts General Hospital
- Massachusetts Institute of Technology
- Harvard University
- European Research Council
- Swedish Research Council
- Swedish Society for Medical Research
- Swedish Cancer Foundation
- Karolinska Institutet
The immune system consists of many specialized cell populations that communicate with each other to achieve systemic immune responses. Our analyses of various measured immune cell population frequencies in healthy humans and their responses to diverse stimuli show that human immune variation is continuous in nature, rather than characterized by discrete groups of similar individuals. We show that the same three key combinations of immune cell population frequencies can define an individual's immunotype and predict a diverse set of functional responses to cytokine stimulation. We find that, even though interindividual variations in specific cell population frequencies can be large, unrelated individuals of younger age have more homogeneous immunotypes than older individuals. Across age groups, cytomegalovirus seropositive individuals displayed immunotypes characteristic of older individuals. The conceptual framework for defining immunotypes suggested by our results could guide the development of better therapies that appropriately modulate collective immunotypes, rather than individual immune components.
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