相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment -Based Drug Design
Katherine L. Lee et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists
Stefan Vollmer et al.
BIOCHEMICAL JOURNAL (2017)
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation
Graham F. Smith et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors
Jennifer Hanisak et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4
William T. McElroy et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation
William T. McElroy et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors
W. Michael Seganish et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4
Jongwon Lim et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly
Ryan Ferrao et al.
MOLECULAR CELL (2014)
Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome
Garrett W. Rhyasen et al.
CANCER CELL (2013)
Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system
Eddy T. H. Goh et al.
BIOCHEMICAL JOURNAL (2012)
MolProbity: all-atom structure validation for macromolecular crystallography
Vincent B. Chen et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
XDS
Wolfgang Kabsch
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
Su-Chang Lin et al.
NATURE (2010)
Regulation of IRAK-1 activation by its C-terminal domain
Thao Nguyen et al.
CELLULAR SIGNALLING (2009)
Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4
Hilary Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys(63)-linked polyubiquitination of IRAK1
Alban Ordureau et al.
BIOCHEMICAL JOURNAL (2008)
IRAK-4 inhibitors. Part 1: A series of amides
George M. Buckley et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
Luke A. J. O'Neill et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Cutting edge:: IL-1 receptor-associated kinase 4 structures reveal novel features and multiple conformations
Andreas Kuglstatter et al.
JOURNAL OF IMMUNOLOGY (2007)
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
Frank H. Niesen et al.
NATURE PROTOCOLS (2007)
Crystal structures of IRAK-4 kinase in complex with inhibitors: A serine/threonine kinase with tyrosine as a gatekeeper
Zhulun Wang et al.
STRUCTURE (2006)
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction
S Uematsu et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling
C Kollewe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
A Strelow et al.
FEBS LETTERS (2003)
Distinct molecular mechanism for initiating TRAF6 signalling
H Ye et al.
NATURE (2002)
IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase
SY Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
H Hemmi et al.
NATURE IMMUNOLOGY (2002)
Negative regulation of toll-like receptor-mediated signaling by Tollip
GL Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A Toll-like receptor recognizes bacterial DNA
H Hemmi et al.
NATURE (2000)
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
K Burns et al.
NATURE CELL BIOLOGY (2000)