期刊
CURRENT OPINION IN PHYSIOLOGY
卷 3, 期 -, 页码 16-24出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cophys.2017.11.006
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资金
- NCI NIH HHS [T32 CA009120, R01 CA185189, P30 CA016042] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007185, R01 GM114188, R01 GM073981] Funding Source: Medline
Each cell in the human body, with the exception of red blood cells, contains multiple copies of mitochondria that house their own genetic material, the maternally inherited mitochondrial DNA. Mitochondria are the cell's powerplant due to their massive ATP generation. However, the mitochondrion is also a hub for metabolite production from the TCA cycle, fatty acid beta-oxidation, and ketogenesis. In addition to producing macromolecules for biosynthetic reactions and cell replication, several mitochondrial intermediate metabolites serve as cofactors or substrates for epigenome modifying enzymes that regulate chromatin structure and impact gene expression. Here, we discuss connections between mitochondrial metabolites and enzymatic writers and erasers of chromatin modifications. We do this from the unique perspective of cell-to-cell mitochondrial transfer and its potential impact on mitochondrial replacement therapies.
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