期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 115, 期 1, 页码 192-197出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1712214114
关键词
deep brain stimulation; nucleus accumbens; delta band; closed loop; reward
资金
- Neurosurgery Research and Education Foundation
- John A. Blume Foundation
- William Randolph Hearst Foundation
- European Society for Stereotactic and Functional Neurosurgery Research Grant
- Stanford Clinical and Translational Science Award (NIH) [UL1 TR 001085]
- Stanford Neuroscience Institute's Neurochoice Initiative
- Stanford's Department of Neurosurgery
- Brain and Behavior Research Foundation
- [K12NS080223]
Reward hypersensitization is a common feature of neuropsychiatric disorders, manifesting as impulsivity for anticipated incentives. Temporally specific changes in activity within the nucleus accumbens (NAc), which occur during anticipatory periods preceding consummatory behavior, represent a critical opportunity for intervention. However, no available therapy is capable of automatically sensing and therapeutically responding to this vulnerable moment in time when anticipation-related neural signals may be present. To identify translatable biomarkers for an off-the-shelf responsive neurostimulation system, we record local field potentials from the NAc of mice and a human anticipating conventional rewards. We find increased power in 1- to 4-Hz oscillations predominate during reward anticipation, which can effectively trigger neurostimulation that reduces consummatory behavior in mice sensitized to highly palatable food. Similar oscillations are present in human NAc during reward anticipation, highlighting the translational potential of our findings in the development of a treatment for a major unmet need.
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