期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 114, 期 21, 页码 5515-5520出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1703477114
关键词
propinquity; autism; social interaction; rodent behavior; genetics
资金
- Louise and Alan Edwards Foundation
- Wellcome Trust [107687/Z/15/Z]
- Brain Canada
- Azrieli Foundation
- Natural Sciences and Engineering Research Council of Canada
- Wellcome Trust [107687/Z/15/Z] Funding Source: Wellcome Trust
Existing assays of social interaction are suboptimal, and none measures propinquity, the tendency of rodents to maintain close physical proximity. These assays are ubiquitously performed using inbred mouse strains and mutations placed on inbred genetic backgrounds. We developed the automatable tube cooccupancy test (TCOT) based on propinquity, the tendency of freely mobile rodents to maintain close physical proximity, and assessed TCOT behavior on a variety of genotypes and social and environmental conditions. In outbred mice and rats, familiarity determined willingness to cooccupy the tube, with siblings and/or cagemates of both sexes exhibiting higher cooccupancy behavior than strangers. Subsequent testing using multiple genotypes revealed that inbred strain siblings do not cooccupy at higher rates than strangers, in marked contrast to both outbred and rederived wild mice. Mutant mouse strains with autistic-like phenotypes (Fmr1(-/y) and Eif4e Ser209Ala) displayed significantly decreased cooccupancy.
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