期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 114, 期 8, 页码 2030-2035出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1615269114
关键词
fMRI; resting-state; rule; cognitive control; functional organization
资金
- Stanford Center for Cognitive and Neurobiological Imaging
- Knut and Alice Wallenberg Foundation (Network Initiative on Culture, Brain, and Learning)
- National Science Foundation Integrative Graduate Education and Research Traineeship [0801700]
Human prefrontal cortex supports goal-directed behavior by representing abstract information about task context. The organizational basis of these context representations, and of representations underlying other higher-order processes, is unknown. Here, we use multivariate decoding and analyses of spontaneous correlations to show that context representations are distributed across subnetworks within prefrontal cortex. Examining targeted prefrontal regions, we found that pairs of voxels with similar context preferences exhibited spontaneous correlations that were approximately twice as large as those between pairs with opposite context preferences. This subnetwork organization was stable across task-engaged and resting states, suggesting that abstract context representations are constrained by an intrinsic functional architecture. These results reveal a principle of fine-scaled functional organization in association cortex.
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