期刊
INTERNATIONAL JOURNAL OF PARTICLE THERAPY
卷 5, 期 1, 页码 84-93出版社
INT JOURNAL PARTICLE THERAPY
DOI: 10.14338/IJPT-18-00024.1
关键词
combination immunotherapy-radiotherapy; heavy-ion radiotherapy; radiation-induced immunogenic cell death; abscopal effect
Clinical trials and case reports of cancer therapies combining radiation therapy with immunotherapy have at times demonstrated total reduction or elimination of metastatic disease. While virtually all trials focus on the use of immunotherapy combined with conventional photon irradiation, the dose-distributive benefits of particles, in particular the distinct biological effects of heavy ions, have unknown potential vis-a-vis systemic disease response. Here, we review recent developments and evidence with a focus on the potential for heavy-ion combination therapy.
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