期刊
ENVIRONMENT INTERNATIONAL
卷 84, 期 -, 页码 71-81出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2015.07.014
关键词
Perfluoroalkyl substances; Endocrine disruptors; Perinatal exposure; Biomonitoring; Profiling
资金
- French National Agency for Research (ANR) [ANR-10-CESA-008]
One major concern regarding perfluoroalkyl acids (PFAAs) is their potential role in onset of health troubles consecutive to early exposure during the perinatal period. In the present work, the internal exposure levels of 18 targeted PFAAs were determined in ca. 100 mother-newborn pairs recruited in France between 2010 and 2013. In serum, the cumulated concentrations of the 7 most frequently detected compounds were 5.70 ng/mL and 2.83 ng/mL (median values) in maternal and cord serum, respectively. Perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexylesulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) contributed to around 90% of the total PFAAs contamination, with concentration levels and contamination profiles in accordance with other published work in Europe. Levels measured in breast milk were far lower (20 to 150 fold) than those determined in serum. Associations between the different monitored substances as well as between levels determined in the different investigated biological matrices mostly do not appear statistically significant. The estimated matemo-foetal transfer would be thus substance-dependant, mainly driven by the physico-chemical properties of the different PFAAs (nature of polar group and length of alkylated side chain). We conclude that trans-placental passage and breastfeeding are both significant routes of human exposure to PFAAs. (C) 2015 Published by Elsevier Ltd.
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