期刊
BMB REPORTS
卷 51, 期 4, 页码 182-187出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2018.51.4.185
关键词
Actomyosin contractility; Glioblastoma; Proinvasive extracellular matrix remodeling; Tumor-associated mesenchymal stem-like cells
资金
- Hanyang University (HY)
- National Research Foundation (NRF)
- Ministry of Science, ICT and Future Planning, Korean Government [NRF-2016R1E1A1A01942075]
In carcinoma, cancer-associated fibroblasts participate in force-mediated extracellular matrix (ECM) remodeling, consequently leading to invasion of cancer cells. Likewise, the ECM remodeling actively occurs in glioblastoma (GBM) and the consequent microenvironmental stiffness is strongly linked to migration behavior of GBM cells. However, in GBM the stromal cells responsible for force-mediated ECM remodeling remain unidentified. We show that tumor-associated mesenchymal stem-like cells (tMSLCs) provide a preinvasive matrix condition in GBM by force-mediated ECM remodeling. Importantly, CCL2-mediated Janus kinase 1 (JAK1) activation increased phosphorylation of myosin light chain 2 in tMSLCs and led to collagen assembly and actomyosin contractility. Collectively, our findings implicate tMSLCs as stromal cells providing force-mediated preinvasive ECM remodeling in the GBM microenvironment, and reminiscent of fibroblasts in carcinoma.
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