期刊
ACS OMEGA
卷 3, 期 5, 页码 5808-5813出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.8b00553
关键词
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资金
- Council of Scientific and Industrial Research (CSIR), New Delhi [02IJ0293)/17/EMR-I]
- Department of Biological Sciences at the University of the Pacific
- U.S. Department of Agriculture, Agricultural Research Service (National Program 108) [CRIS 5325-42000-049-00D]
- University Grants Commission (UGC), New Delhi, India, under UGC-JRF Fellowship
In this study, we outline the synthesis of isatin-ferrocenyl chalcone and 1H-1,2,3-triazole-tethered isatin-ferrocene conjugates along with their antimicrobial evaluation against the human mucosal pathogen Trichomonas vaginalis. The introduction of a triazole ring among the synthesized conjugates improved the activity profiles with most of the compounds in the library, exhibiting 100% growth inhibition in a preliminary susceptibility screen at 100 mu M. IC50 determination of the most potent compounds in the set revealed an inhibitory range between 2 and 13 mu M. Normal flora microbiome are unaffected by these compounds, suggesting that these may be new chemical scaffolds for the discovery of new drugs against trichomonad infections.
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