期刊
POLYMER CHEMISTRY
卷 8, 期 2, 页码 472-484出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6py01526c
关键词
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资金
- National Natural Science Foundation of China [21174160, 21372251]
- Chinese Academy of Sciences (CAS)
- Youth Innovation Promotion Association (YIPA) [2012204]
A series of diblock amphiphilic glycopolypeptide analogues poly(6-O-methacryloyl-D-galactopyranose)-SS-poly(gamma-benzyl-L-glutamate) (PMAgala-SS-PBLG) with well-defined and tunable structure, and redox-responsive disulfide linkage were prepared through a combination of modulated reactions including RAFT polymerization, ring-opening polymerization, click coupling reaction and following TFA-mediated deprotection, and a non-disulfide analogue PMAgala(27)-CC-PBLG(30) was prepared as a control. Molecular structures of the above prepared PMAgala-b-PBLG glycopolypeptide analogues were further characterized and their self-assembly properties were examined. The glycopolypeptide analogues were able to form stabilized micelles (with alpha-helix PBLG cores) and the uniform-sized PMAgala-SS-PBLG micelles exhibited obvious redox-responsive features in the presence of glutathione (GSH), whereas the non-disulfide control did not show such change. For biological applications, the lectin recognition properties, doxorubicin (DOX) delivery manner and human hepatoma cell receptor targeting capabilities were further evaluated. The results illustrated that the PMAgala-b-PBLG glycopolypeptide analogues might serve as redox-responsive, highly biocompatible multifunctional biomaterial platforms for practical applications.
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