期刊
CHINESE JOURNAL OF NATURAL MEDICINES
卷 16, 期 5, 页码 358-365出版社
CHINESE JOURNAL NATURAL MEDICINES
DOI: 10.1016/S1875-5364(18)30068-2
关键词
Mangrove; Penicillium sp.; Sorbicillin derivative; Diketopiperazine alkaloids
资金
- Natural Science Foundation of China [81520108028]
- SCTSM Projects [14431901100, 15431901000]
- SKLDR/SIMM Project [SIMM1501ZZ-03]
One new sorbicillin derivative, 2-deoxy-sohirnone C (1), one new diketopiperazine alkaloid, 5S-hydroxynorvaline-S-Ile (2), and two naturally occurring diketopiperazines, 3S-hydroxylcyclo(S-Pro-S-Phe) (3) and cyclo(S-Phe-S-Gln) (4), together with three known compounds were isolated from the Chinese mangrove endophytic fungus Penicillium sp. GD6. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison with literature data. The absolute configuration of 3-hydroxyl moiety in 3 was determined by Mosher's method, while the absolute stereochemistry of 2 and 4 was established by comparison with the CD spectra of natural and synthesized diketopiperazines. Compound 1 showed moderate antibacterial activity against Methicillin-resistant Staphylococcus aureus with a MIC value of 80 mu g.mL(-1).
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