Copper(II) bis-thiazole complex immobilized on silica nanoparticles: Preparation, characterization and its application as a highly efficient catalyst for click synthesis of 1,2,3-triazoles

In this work, the preparation of copper(II) complex of 3,5-bis(2-benzothiazolyl)pyridine, Cu(II)Br-2-BTP, supported on nano silica functionalized with trimethoxysilylpropylchloride, Cu(II)Br-2-BTP@TMSPnSiO(2), is reported. The prepared catalyst was characterized by different analytical techniques such as elemental analysis, FT-IR, H-1 NMR, ICP-OES, XPS and UV-Vis spectroscopic methods, and also SEM and TEM microscopic techniques. This heterogeneous catalyst showed excellent activity in the click synthesis of 1,2,3-triazoles via one-pot three-component reaction of alkynes, organic halides, and sodium azide. Moreover, the catalyst was applied for synthesis of 1,2,3-triazoles by the reaction of alpha-bromoketones, alkyl/aryl terminal alkynes and sodium azide. The heterogeneous catalyst was reused several times without any decrease in its catalytic activity. (C) 2017 Elsevier Ltd. All rights reserved.