期刊
ACS OMEGA
卷 3, 期 3, 页码 3513-3521出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.7b01844
关键词
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资金
- SERB-DST, New Delhi [EMR/2016/001643]
- CSIR
- UGC-New Delhi
- SERB-DST
An environment-friendly method for the chlorination of imidazoheterocycles has been developed using chloramineT, a novel chlorinating reagent. A bunch of C-3 chloro-substituted imidazo[1,2-a]pyridines with variety of functionalities have been synthesized in good yields under neat condition at room temperature within very short time. This chlorination process is also applicable to imidazo[2,1-b]thiazole scaffolds. The present methodology is relevant to gram-scale synthesis. The major advantages of this system such as wide applicability, easy availability of reactants, open-air and metal- and solvent-free reaction conditions, no need of work-up, and simple purification technique represent a green synthetic protocol.
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