期刊
ALLERGY
卷 70, 期 6, 页码 674-681出版社
WILEY
DOI: 10.1111/all.12599
关键词
airway hyperresponsiveness; asthma; children; periostin
资金
- Hallym University [HURF-2013-10]
- Grants-in-Aid for Scientific Research [15K15372, 25293224] Funding Source: KAKEN
BackgroundPeriostin is a matricellular protein, and its synthesis in airway epithelial cells and lung fibroblasts is induced by interleukin (IL)-4 and IL-13. The significance of periostin as a biomarker of T(H)2-induced airway inflammation, and (importantly) as a measure of the response to T(H)2-targeted therapy, has recently been emphasized. We explored the relationship between periostin and airway hyperresponsiveness (AHR) in asthmatic children. MethodsThe study included 83 children aged 6-15years in an asthmatic group (n=54) and healthy controls (n=29). We measured the periostin levels in serum and performed methacholine and mannitol provocation challenges. The responses to mannitol were expressed as the provocative dose causing a 15% fall in the FEV1 (the PD15 dose). ResultsOf the 54 subjects with asthma, all had positive methacholine bronchial provocation test (BPT) results and 38 had positive mannitol BPT results. Children with asthma had significantly higher periostin levels than controls [76.0 (65.0-91.8) vs 71.0 (57.5-80.0) ng/mL; P=0.017]. Periostin levels were significantly correlated with both the methacholine PC20 and mannitol PD15 values. ConclusionSerum levels of periostin, a new biomarker induced by IL-13, were higher in asthmatic children, and were associated with AHR to methacholine and mannitol.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据