期刊
BIOMARKER RESEARCH
卷 6, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s40364-018-0134-y
关键词
Chemerin; Multiple myeloma; Adipocyte; Stromal cell
资金
- Norwegian Cancer Society [4500930]
- Kristian Gerhard Jebsen Foundation [SKGJ-MED-007]
- Norwegian Research Council [223255, 193072]
- Liaison Committee for education, research and innovation in Central Norway [9006100]
- Cancer Fund (Kreftfondet) at St Olavs Hospital, Trondheim
Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma.
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