期刊
JOURNAL OF EXPERIMENTAL NEUROSCIENCE
卷 12, 期 -, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1179069518786715
关键词
Parkinson disease; MRI; alpha-synuclein; deformation brain morphometry; prion
资金
- Canadian Institutes of Health Research
- Michael J. Fox Foundation for Parkinson's Research
- W. Garfield Weston Foundation
- Alzheimer's Association
- Natural Sciences and Engineering Research Council of Canada
- Healthy Brain for Healthy Lives Discovery Award
One of the most exciting recent hypotheses in neurology is that most neurodegenerative diseases are caused by the neuron to neuron propagation of prion-like misfolded proteins. In Parkinson disease, the theory initially emerged from postmortem studies demonstrating a caudal-rostral progression of pathology from lower brainstem to neocortex. Later, animal studies showed that the hallmark protein of PD, alpha-synuclein, exhibited all the characteristics of a prion. Here, we describe our work using human neuroimaging to test the theory that PD pathology advances via a propagating process along the connectome. We found that the pattern and progression of brain atrophy follow neuronal connectivity, correlate with clinical features, and identify an epicenter in the brainstem.
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