期刊
ACS APPLIED BIO MATERIALS
卷 1, 期 1, 页码 42-50出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.8b00004
关键词
bacterial cellulose; three-dimensional network; polyethylenimine; aspirin; controlled release
资金
- National Natural Science Foundation of China [51572124, 21504045, 51573079, 51702162]
- Fundamental Research Funds for the Central Universities [30916012201, 30915012202, 30916014102]
- Nanjing University of Science and Technology
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD, China)
- Qing-Lan Project from Jiangsu Education Department
- Postgraduate Research and Practice Innovation Program of Jiangsu Province
The development of low-cost biological materials with controlled drug release profile is of great importance but challenging in pharmaceutical industry. Recently, bacterial cellulose nanofibers have provoked intensive research interests in tissue engineering and the pharmaceutical science due to their stability, availability, sustainability, and low toxicity. Here we describe the development of a PEI (polyethylenimine)-grafted bacterial cellulose (BC) as an efficient drug delivery system. The PEI-BC aerogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis, and zeta potential measurements. The optimum sample exhibited enhanced mechanical strength, remarkable adsorption capacity toward aspirin, BSA, and gentamicin, prolonged and pH-dependent drug release, and low cytotoxicity. Our work has presented a rational structure design from biomass for controllable drug carrier.
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