期刊
ACS APPLIED BIO MATERIALS
卷 1, 期 1, 页码 21-26出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.8b00005
关键词
peptide amphiphile; lysine; antibacterial activity; aggregate; gemini amphiphile
资金
- National Natural Science Foundation of China [21761142007, 21773261, 91527306]
Gemini-type peptide amphiphiles 12-(Lys)(n)-12 (n = 2, 4, 6) with different lysine spacer lengths have been established and exhibit excellent antibacterial activities. By varying the lysine number in the spacer, the distinct aggregates with zero- to three-dimensional structures (fibers, short rods, and spherical aggregates) are formed. These different length/diameter ratios of aggregates have great effects on the antibacterial activities and cytotoxicity. 12-(Lys)(2)-12 has a relatively higher minimal inhibitory concentration (MIC) value and shows toxicity toward mammalian cells just above its MIC value, while 12-(Lys)(4)-12 and 12-(Lys)(6)-12 have lower MIC values and no cytotoxicity even at 5 times the MIC values.
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