期刊
TRANSCRIPTION-AUSTIN
卷 9, 期 2, 页码 88-94出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21541264.2017.1281864
关键词
7SK snRNP; Brd4; KAP1; promoter-proximal pausing; P-TEFb; RNA Pol II; SEC; transcription elongation
资金
- National Natural Science Foundation of China [81361120386, 31570751, 31270809, 30930046, 31501096]
- 973 program [2013CB917802]
- Fundamental Research Funds for the Central Universities [20720150053]
- NSFC for Fostering Talents in Basic Research [J1310027]
- [NIH-CA179511]
The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.
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