期刊
PLANT JOURNAL
卷 90, 期 4, 页码 628-653出版社
WILEY
DOI: 10.1111/tpj.13520
关键词
translation; upstream open reading frames; internal ribosomal entry sites; gene-specific translation; global regulation of translation; RNA-binding protein
资金
- NSF [IOS1444561, IOS1650139]
- program Contratos Postdoctorales para la Captacion de Talento para la Investigacion en la Universidad de Malaga (Spain)
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1444561] Funding Source: National Science Foundation
Changes in gene expression are at the core of most biological processes, from cell differentiation to organ development, including the adaptation of the whole organism to the ever-changing environment. Although the central role of transcriptional regulation is solidly established and the general mechanisms involved in this type of regulation are relatively well understood, it is clear that regulation at a translational level also plays an essential role in modulating gene expression. Despite the large number of examples illustrating the critical role played by translational regulation in determining the expression levels of a gene, our understanding of the molecular mechanisms behind such types of regulation has been slow to emerge. With the recent development of high-throughput approaches to map and quantify different critical parameters affecting translation, such as RNA structure, protein-RNA interactions and ribosome occupancy at the genome level, a renewed enthusiasm toward studying translation regulation is warranted. The use of these new powerful technologies in well-established and uncharacterized translation-dependent processes holds the promise to decipher the likely complex and diverse, but also fascinating, mechanisms behind the regulation of translation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据