期刊
ALLERGY
卷 71, 期 2, 页码 137-148出版社
WILEY
DOI: 10.1111/all.12770
关键词
allergic inflammation; Asthma; bronchial epithelium; dendritic cells
资金
- Fondation Saint-Luc
- Cliniques universitaires St-Luc
- Fondation de Vooght, Universite catholique de Louvain (UCL), Belgium
- Secteur des Sciences de la Sante - Institut de Recherche Experimentale & Clinique, Universite catholique de Louvain (UCL), Belgium
- Fonds National pour la Recherche Scientifique (FNRS), Belgium [FRSM 3.4522.12]
- GSK, Belgium
The role of dendritic cells (DCs) in airway allergy has been studied for 15years; recent data has highlighted the cross talk with airway epithelial cells and environmental factors (allergens, virus) during the inception and exacerbation of allergic asthma. Although murine models have provided key information, it remains uncertain to what extent these basic mechanisms take place in human allergic disease, notably with regard to different clinical phenotypes. In the present review, we discuss new evidence regarding mechanisms of DC regulation in the mouse which could be important in human asthma. Finally, after discussing the effects of current therapies on DC biology, we focus on pathways that could represent targets for future therapies.
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