期刊
CELLULAR AND MOLECULAR BIOLOGY
卷 64, 期 5, 页码 80-84出版社
C M B ASSOC
DOI: 10.14715/cmb/2018.64.5.13
关键词
Melanogenesis; Tyrosinase; MITF; Poria cocos Wolf; B16F10; Whitening
资金
- National Research Foundation of Korea (NRF) - Ministry of Education [2017R1D1A1B03028380]
- National Research Foundation of Korea [2017R1D1A1B03028380] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In skin, melanocytes determine skin color using melanogenesis, which induces protective mechanism to oxidative stress and ITV damage. However, when melanin is excessive produced by the various stimulus, the accumulated melanin induces hyperpigmentation disease such as melasma, freckles, Melanism ware induced. Therefore, it is implicated to finding potential agents for whitening to be used in cosmetic products. In our present study, we show that Poria cocos Wolf extracts decreased melanin synthesis in B16F10. And then this inhibition of melanogenesis was provoked by regulation of tyrosinase activity and tyrosinase and MITF expression. Moreover, Poria cocos Wolf extracts contained cream improved skin tone using increase of bright value. Overall, these results provide evidence to potential agent for whitening to be used in cosmetic products.
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