期刊
BLOOD ADVANCES
卷 2, 期 13, 页码 1651-1663出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/bloodadvances.2018018903
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资金
- Lund University
- Crafoordska Stiftelsen [20170829]
- Vetenskapsradet (Swedish Research Council, VR) [2017-01779]
- Avtal om Lakarutbildning och Forskning
- Canadian Blood Services [340668]
- Health Canada
- Royal Physiographic Society of Lund
- Canadian Blood Services
- Swedish Research Council [2017-01779] Funding Source: Swedish Research Council
Transfusion-related acute lung injury (TRALI) is a syndrome of respiratory distress upon blood transfusion and is the leading cause of transfusion-related fatalities. Whether the gut microbiota plays any role in the development of TRALI is currently unknown. We observed that untreated barrier-free (BF) mice suffered from severe antibody-mediated acute lung injury, whereas the more sterile housed specific pathogen-free (SPF) mice and gut flora-depleted BF mice were both protected from lung injury. The prevention of TRALI in the SPF mice and gut flora-depleted BF mice was associated with decreased plasma macrophage inflammatory protein-2 levels as well as decreased pulmonary neutrophil accumulation. DNA sequencing of amplicons of the 16S ribosomal RNA gene revealed a varying gastrointestinal bacterial composition between BF and SPF mice. BF fecal matter transferred into SPF mice significantly restored TRALI susceptibility in SPF mice. These data reveal a link between the gut flora composition and the development of antibody-mediated TRALI in mice. Assessment of gut microbial composition may help in TRALI risk assessment before transfusion.
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