期刊
PIGMENT CELL & MELANOMA RESEARCH
卷 30, 期 4, 页码 402-412出版社
WILEY
DOI: 10.1111/pcmr.12592
关键词
chemical genetic screen; melanoma initiation; metastasis; personalized medicine; zebrafish melanoma model
资金
- Netherlands Organization for Scientific Research (NWO) Rubicon Fellowship
- Dutch Cancer Foundation (KWF) Fellowship
- Boehringer Ingelheim Fonds PhD Fellowship
- Melanoma Research Alliance (MRA) [R01 CA103846]
- Ellison Foundation
Melanoma is the most aggressive and deadliest form of skin cancer. A detailed knowledge of the cellular, molecular, and genetic events underlying melanoma progression is highly relevant to diagnosis, prognosis and risk stratification, and the development of new therapies. In the last decade, zebrafish have emerged as a valuable model system for the study of melanoma. Pathway conservation, coupled with the availability of robust genetic, transgenic, and chemical tools, has made the zebrafish a powerful model for identifying novel disease genes, visualizing cancer initiation, interrogating tumor-microenvironment interactions, and discovering new therapeutics that regulate melanocyte and melanoma development. In this review, we will give an overview of these studies, and highlight recent advancements that will help unravel melanoma pathogenesis and impact human disease.
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