Vitis amurensis Rupr: A review of chemistry and pharmacology

Purpose: Vitis amurensis Rupr. from the family Vitaceae, is a grape species native to the Asian continent. It is a highly attractive plant, used widely worldwide. It has been used for several hundred years as a traditional Chinese herb. The review focuses on the botanical description, traditional uses, phytochemistry, and the biological activities of Vitis amurensis Rupr. to evaluate its therapeutic potential uses. Methods: This review summarizes the published data concerning the botanical aspects, traditional usage, phytochemistry, and pharmacology of Vitis amurensis Rupr., to evaluate its therapeutic potential as an important source of natural compounds with effect activities that benefit human health. Results: Vitis amurensis Rupr. has been used for several hundred years as a traditional Chinese herb to treat stranguria, rheumatoid arthritis-associated edema, chronic hepatitis, nephritis, chronic arthritis and traumatic hemorrhage. It is a particularly rich source of the oligostilbenes, flavonoids, and anthocyanins, phytochemicals that are associated with antioxidant, anti-inflammatory, antibacterial and cardioprotective activities. Due to the presence of a multitude of bioactives, a wide array of pharmacological activities have been ascribed to different parts of this herb and individual compounds, which include antioxidant, antimicrobial, anti-inflammatory, anticancer, anti-aging, anti-melanogenic, anti-allergic and anti-viral. Conclusion: From a health perspective, Vitis amurensis Rupr. presents excellent options for treating various diseases due to its bioactive compounds (drug candidates) that exhibit important activities or for developing new products.