期刊
PHYTOCHEMISTRY LETTERS
卷 20, 期 -, 页码 168-171出版社
ELSEVIER
DOI: 10.1016/j.phytol.2017.04.037
关键词
Przewalskia tangutica; Solanaceae; Chlorinated phenolic glycoside; Cytotoxic activity
资金
- National Natural Sciences Foundation of China [21402157, 21572219]
- Syngenta Postgraduate Fellowship
Three new chlorinated phenolic glycosides, namely przewatangosides A-C (1-3), along with one known compound, globosumoside A (4), were isolated from the whole plants of Przewalskia tangutica. Their structures were unequivocally determined by extensive spectroscopic analysis and chemical method. The cytotoxic activities of the isolated phenolic glycosides (1-4) were evaluated against the five human cancer cell lines A549, MCF-7, SMMC-7721, HepG2 and HL-60. Przewatangoside A (1) exhibited weak cytotoxicity against SMMC-7721 with the IC50 value of 38.1 mu M. All the tested compounds were inactive (IC50 > 50 mu M) to the normal human hepatocyte cell line (L02).
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