期刊
PHYTOCHEMISTRY
卷 141, 期 -, 页码 156-161出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2017.05.010
关键词
Valeriana jatamansi; Caprifoliaceae; Iridoids; Cytotoxicity; Neuroprotective activity
资金
- National Science Foundation for Fostering Talents in Basic Research of the National Natural Science Foundation of China fund [J13100340-11]
- key fund project for Education Department of Sichuan [15ZA0093]
- youth science and technology innovative research team fund project of Sichuan [2016TD0006]
- project for administration of Traditional Chinese Medicine [2016Q049]
Five iridoids, named as chlorovaltrate P-T, together with six known analogues, (48,88)-8-methoxy-3-methoxy-10-methylene-2,9-dioxatricyclo[4.3.1.0(3,7)]decan-4-ol, chlorovaltrate A, (1R,3R,5R,7S,8R,9S)-3,8-epoxy-1-O-ethyl-5-hydroxyvalechlorine, 8-methoxy-4-acetoxy-3-chlormethyl-10-methylen-2,9-dioxa-tricyclo[4.3.1.0(3,7)]decan, (1S,3R,5R,7S,8R,9S)-3,8-epoxy-1-O-ethyl-5-hydroxyvalechlorine, (1R,3R,5R,7S,8R,9S)-3,8-epoxy-1-O-methyl-5-hydroxyvalechlorine were isolated from the roots of Valeriana jatamansi (syn. Valeriana wallichii). Their structures were elucidated by extensive analysis of 1D, 2D NMR and HRESIMS spectroscopic. The absolute configuration of chlorovaltrate P-T were established by comparing their experimental and calculated electronic circular dichroism (ECD) spectra. 3,8-epoxy iridoids exhibited weak cytotoxicity against the lung adenocarcinoma (A-549) and gastric carcinoma cells (SGC 7901). Some also showed moderate neuroprotective effects against CoCl2-induced neuronal cell death in PC12 cells. (C) 2017 Elsevier Ltd. All rights reserved.
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