期刊
PHYTOCHEMISTRY
卷 137, 期 -, 页码 148-155出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2017.02.009
关键词
Nicandra physalodes; Solanaceae; Withanolides; Cytotoxicity
资金
- Major Program of the National Knowledge Innovation of CAS [KSCX2-YW-G-038]
- Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2015-ZZ09]
Twenty withanolides, including previously unknown nicanlodes A-M, were isolated from aerial parts of Nicandra physalodes. Their structural elucidations were unambiguously achieved through interpretation of extensive spectroscopic data (NMR and HRMS) and by comparison with literature data. Nicanlodes A and B have an unusual aromatic amine moiety. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines. (C) 2017 Published by Elsevier Ltd.
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