期刊
PHYTOCHEMISTRY
卷 139, 期 -, 页码 98-108出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2017.04.011
关键词
Aquilaria sinensis; Thymelaeaceae; Artificial agarwood; 5,6,7,8-Tetrahydro-2-(2-phenylethyl)chromones; AChE inhibitory activity
资金
- Special Fund for Agro-scientific Research in the Public Interest [201303117]
- Special Fund for Engineering Technology Research Center of Hainan Province [gczx2015005]
- Special Fund for Basic Scientific Research of Institute of Tropical Bioscience and Biotechnology [ITBB2015ZY03]
- Major Technology Project of Hainan Province [ZDKJ2016004-03]
Thirteen previously undescribed 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones named tetrahydrochromone A-M, together with nine known ones, were isolated from artificial agarwood (induced by holing) originating from Aquilaria sinensis (Lour.) Gilg. The structures of these compounds were unambiguously determined based on extensive NMR spectroscopic analyses, and the absolute configuration was resolved by CD analyses, X-ray crystallographic, chemical and Mosher's method. Tetrahydrochromone A, B, K-M, and Oxidoagarochromone An exhibited inhibitory activity against AChE with the percentage inhibition range from 17.5% to 47.9% (with Tacrine as the positive control; inhibition ratio: 66.7%) when tested at 50 mu g/mL. Tetrahydrochromone A-E, F-J feature one methoxy and three hydroxys linked at the cyclohexene ring rather than usual four hydroxys, and tetrahydrochromone K-M represent the first examples of 7,8-epoxy tetrahydrochromones. (C) 2017 Elsevier Ltd. All rights reserved.
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