期刊
ARKIVOC
卷 -, 期 -, 页码 240-256出版社
ARKAT USA INC
DOI: 10.24820/ark.5550190.p010.159
关键词
Thiazole; dihydroquinolone; bis(thiazol-5-yl)methane; antibacterial; antioxidant activity
Novel functionalized thiazoles were prepared by the Hantzsch reaction from 3-[(4-hydroxyphenyl)carbamothioylamino]-2-methylpropanoic acid and the corresponding alpha-halocarbonyl compounds in good yields. A series of chemical transformations of the obtained products were carried out, and new functionalized thiazole derivatives with aliphatic, aromatic and heterocyclic substituents were synthesized. 4-Phenyl-substituted N-(4-hydroxyphenyl)-N-carboxyalkylaminothiazoles were used as precursors for the synthesis of bis(thiazol-5-yl)methane derivatives, which then were screened for their antibacterial, antioxidant activities. [GRAPHICS] .
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