期刊
PHYSIOLOGY & BEHAVIOR
卷 177, 期 -, 页码 221-229出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2017.05.002
关键词
Light; Spectrum; Melatonin; Sleep; Alertness; Circadian
资金
- Biological Illuminations LLC
- NIH/NHLBI [T32-HL007901]
- Harvard Clinical and Translational Science Center, from the National Center for Advancing Translational Sciences [1 UL1 TR 001102, 8 UL1 TR000170-05]
We compared the effects of bedroom-intensity light from a standard fluorescent and a blue- (Le., short wavelength) depleted LED source on melatonin suppression, alertness, and sleep. Sixteen healthy participants (8 females) completed a 4-day inpatient study. Participants were exposed to blue-depleted circadian-sensitive (C LED) light and a standard fluorescent light (FL, 4100 K) of equal illuminance (50 lx) for 8 h prior to a fixed bedtime on two separate days in a within-subject, randomized, cross-over design. Each light exposure day was preceded by a dim light ( < 3 lx) control at the same time 24 h earlier. Compared to the FL condition, control adjusted melatonin suppression was significantly reduced. Although subjective sleepiness was not different between the two light conditions, auditory reaction times were significantly slower under C-LED conditions compared to FL 30 min prior to bedtime. EEG-based correlates of alertness corroborated the reduced alertness under C-LED conditions as shown by significantly increased EEG spectral power in the delta-theta (0.5-8.0 Hz) bands under C-LED as compared to FL exposure. There was no significant difference in total sleep time (TST), sleep efficiency (SE%), and slow-wave activity (SWA) between the two conditions. Unlike melatonin suppression and alertness, a significant order effect was observed on all three sleep variables, however. Individuals who received C-LED first and then FL had increased TST, SE% and SWA averaged across both nights compared to individuals who received FL first and then C-LED. These data show that the spectral characteristics of light can be fine-tuned to attenuate non-visual responses to light in humans.
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