期刊
PHYSIOLOGY
卷 32, 期 3, 页码 182-196出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00025.2016
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资金
- NIH [UH3-TR-000954, R01-HL-111121, R01-AG-053832]
- Minnesota Biotechnology and Genomics Partnership Grant
Our understanding of the fundamental biology and identification of efficacious therapeutic targets in aortic valve stenosis has lagged far behind the fields of atherosclerosis and heart failure. In this review, we highlight the most clinically relevant problems facing men and women with fibrocalcific aortic valve stenosis, discuss the fundamental biology underlying valve calcification and fibrosis, and identify key molecular points of intersection with sex hormone signaling.
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