期刊
NATURE REVIEWS IMMUNOLOGY
卷 18, 期 8, 页码 485-497出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41577-018-0020-8
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资金
- Intramural Research Program of the US Eunice Kennedy Shriver National Institute of Child Health and Human Development [1ZIAHD001803-19]
- INSERM, France
The remarkable T cell receptor (TCR) performs essential functions in the initiation of intracellular signals required for T cell development, repertoire selection and effector responses to foreign antigens. How TCR signals elicit such diverse cellular responses and outcomes remains a major question for investigation. Recent years have witnessed important advances in our understanding of the regulatory processes that control and modulate the TCR signalling response. Here, we review newly identified mechanisms for the regulation of TCR signalling and then discuss how the TCR signalling response is regulated to control two critical cellular processes - namely, positive selection and T cell homeostasis.
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